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Ginkgolide - Wikipedia

https://en.wikipedia.org/wiki/Ginkgolide

Ginkgolides are biologically active terpenic lactones present in Ginkgo biloba. They are diterpenoids with 20-carbon skeletons, which are biosynthesized from geranylgeranyl pyrophosphate. [1]

Frontiers | Role of Ginkgolides in the Inflammatory Immune Response of ...

https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2020.00045/full

Ginkgolides have several different biological effects including inhibiting platelet aggregation, preventing apoptosis and oxidation, providing nutrition to nerves, and regulating neuroimmunity.

Ginkgolide - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/chemistry/ginkgolide

Ginkgolides are pharmacologically-active diterpenes found in Ginkgo biloba (Ginkgoaceae), which have been widely reported to have several pharmacological properties, including anti-inflammatory effects; for example, Ginkgolides A–C, J and M (Fig. 4).

Ginkgolides and Their Derivatives: Synthetic and Bioorganic Studies

https://link.springer.com/chapter/10.1007/978-3-7091-0442-2_12

The isolation of ginkgolides from Ginkgo biloba extracts represents the main source of these trilactones for all synthetic, structural, and biological studies. However, some ginkgolides are more abundant in the extracts than others.

Biosynthesis pathways of ginkgolides - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC3731879/

This review focuses on the biosynthetic pathways of ginkgolides, the enzymes related to the biosynthesis of the ginkgolides, the genes encoding the enzymes cloned from the ginkgo, and the factors influencing the production of ginkgolides in cell cultures.

Ginkgolide A: Uses, Interactions, Mechanism of Action - DrugBank Online

https://go.drugbank.com/drugs/DB06743

This compound belongs to the class of organic compounds known as ginkgolides and bilobalides. These are diterpene lactones with a structure based either on the gingkolide or the bilobalide skeleton. The ginkgolide skeleton is a very rigid structure consisting of hexacyclic C20 trilactone.

Ginkgolide - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/neuroscience/ginkgolide

The ginkgolides are a unique class of diterpenoids isolated from the ‘fossil’ tree Ginkgo biloba L. This tree is the only remaining species of the Ginkgoales, once a very large order, and its extreme botanical position is matched by the unusual chemistry of its constituents.

Role of Ginkgolides in the Inflammatory Immune Response of Neurological ...

https://pmc.ncbi.nlm.nih.gov/articles/PMC7411855/

Ginkgolides are natural PAFR antagonists that selectively and competitively antagonize PAF-induced platelet aggregation (Gui et al., 2007). It is well established that PAF signaling plays a pivotal role in the initiation and progression of inflammatory and thrombotic reactions, as well as in the cross talk between them (Stafforini et al., 2003).

Ginkgolides and bilobalide: Their physical, chromatographic and ...

https://www.sciencedirect.com/science/article/pii/S0968089605004761

Ginkgolides A, B, C, J, K, L and M and bilobalide are rare terpene trilactones that have been isolated from leaves and root bark of the Chinese tree Ginkgo biloba. The structures of the highly oxidized ginkgolides were independently elucidated in the 1960s by the groups of Nakanishi and Sakabe.

Therapeutic promises of ginkgolide A: A literature-based review

https://pubmed.ncbi.nlm.nih.gov/33254431/

Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of sc …

Ginkgolide - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/medicine-and-dentistry/ginkgolide

Ginkgolides are diterpenoid trilactone-containing unique C20 lactone cage molecules that are the main principles from the slow-growing Ginkgo biloba L. (especially from leaf part), which are from gymnospermous tree, species in the division ginkgophyta, and a single surviving species belonging to the family of ginkgoaceae in a class of ...

Ginkgolide - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/ginkgolide

Ginkgolides are diterpenoid trilactone-containing unique C 20 lactone cage molecules that are the main principles from the slow-growing Ginkgo biloba L. (especially from leaf part), which are from gymnospermous tree, species in the division ginkgophyta, and a single surviving species belonging to the family of ginkgoaceae in a class of ...

Ginkgo wetenschappelijk bekeken - Mens en Gezondheid

https://mens-en-gezondheid.infonu.nl/natuurgeneeswijze/83239-ginkgo-wetenschappelijk-bekeken.html

De ginkgolides zijn de meest krachtige en selectieve PAF (Platelet-Activating Factor)-antagonisten die er tot nu toe gevonden zijn. PAF is een sterk werkzame lichaamseigen stof die een rol speelt in veel pathologische situaties.

Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A ...

https://pubs.acs.org/doi/10.1021/jacs.2c08351

The highly complex molecular architecture of ginkgolides, combined with their remarkable biological profile, provides a unique platform for the development of new strategies and methods. Herein, we reported the first total synthesis of ginkgolide C and the formal syntheses of ginkgolides A and B.

Ginkgo biloba - Natura Foundation

https://www.naturafoundation.nl/kenniscentrum/monografie/53/ginkgo-biloba

“The ginkgolides: potent platelet-activating factor antagonist isolated from Ginkgo biloba”, Drugs of the future, 1987. Oberplichter H. et al.: “PAF-antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus”, Journal of cerebral blood flow and metabolism, 1990.

Identification of a central regulator of ginkgolide biosynthesis in

https://pubmed.ncbi.nlm.nih.gov/39903108/

Ginkgolides are secondary metabolites unique to Ginkgo biloba with the potential to prevent and treat cardiovascular and cerebrovascular diseases. Although the biosynthetic pathways of ginkgolides have been partly uncovered, the mechanism regulating their biosynthesis is still largely unknown.

Ginkgo Biloba : Gebruik, Bijwerkingen en Dosering - Gezondheidswinkel

https://degezondheidswinkel.be/blog/ginkgo-biloba-gebruik-bijwerking-dosering/

Ginkgo Biloba bevat de antioxidante stoffen ginkgo flavone glycosiden, terpene moleculen (ginkgolides en bilobalide) alsook organische zuren. Antioxidanten bevechten de schadelijke effecten van vrije radicalen.

Ginkgo biloba, werkingsmechanismen en klinische toepassingen - Orthokennis

https://www.orthokennis.nl/artikelen/ginkgo-biloba

PAF-antagonisme, ontstekingsremmende activiteit Ginkgo-extract (met name ginkgolides) is een antagonist van PAF (platelet activating factor). PAF bevordert bloedplaatjesaggregatie, is een krachtige ontstekingsmediator en bevordert ontstekingen, allergische reacties, ischemie/reperfusieschade, pijn, oedeem, trombose en vrije ...

Ginkgo biloba - SOHF

https://www.sohf.nl/nutrienten/ginkgo-biloba

The Ginkgo biloba extract EGb 761 and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol 2010;159:659-68.

Neuroregulatory role of ginkgolides | Molecular Biology Reports - Springer

https://link.springer.com/article/10.1007/s11033-021-06535-2

The neuroregulative properties of ginkgolides include the conditioning of neurotransmitters action, e.g., glutamate or dopamine. Besides, natural compounds induce the inhibition of platelet-activating factors (PAF). Furthermore, ginkgolides influence the inflammatory process.