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Ginkgolide - Wikipedia

https://en.wikipedia.org/wiki/Ginkgolide

Ginkgolides are biologically active terpenic lactones present in Ginkgo biloba. They are diterpenoids with 20-carbon skeletons, which are biosynthesized from geranylgeranyl pyrophosphate.

The neuroprotective mechanisms of ginkgolides and bilobalide in ...

https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0125-y

The ginkgolides and bilobalide that constitute a critical part of EGb761 have demonstrated protective properties towards cerebral injury. Ginkgolides include Ginkgolide A (GA), Ginkgolide B (GB), Ginkgolide C (GC), Ginkgolide J (GJ), Ginkgolide K (GK), Ginkgolide L (GL), and Ginkgolide M (GM).

Total synthesis of (.+-.)-ginkgolide B | Journal of the American ...

https://pubs.acs.org/doi/10.1021/ja00210a083

Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B. Journal of the American Chemical Society 2022, 144 (39) , 17792-17796. https://doi.org/10.1021/jacs.2c08351. Kenji Ota, Kazunori Nagao, Hirohisa Ohmiya.

Ginkgolide A: Uses, Interactions, Mechanism of Action - DrugBank Online

https://go.drugbank.com/drugs/DB06743

Ginkgolide A. Star 0. Generic Name. Ginkgolide A. DrugBank Accession Number. DB06743. Background. Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders.

Ginkgolide B | C20H24O10 | CID 11973122 - PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/11973122

Ginkgolide B | C20H24O10 | CID 11973122 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

The neuroprotective mechanisms of ginkgolides and bilobalide in ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925848/

In this review, we hope to provide the readers with an overview of current understanding of the neuroprotective effects and mechanisms of ginkgolides and bilobalide in cerebral injury following ischemic strokes. Ginkgolides and bilobalide are unique terpenoid components of the Ginkgo biloba tree.

Japanse notenboom - Wikipedia

https://nl.wikipedia.org/wiki/Japanse_notenboom

De Japanse notenboom, ginkgo, tempelboom of eendenpootboom [2] ( Ginkgo biloba, synoniem: Salisburia adiantifolia Sm.) is een boom uit de familie Ginkgoaceae. De soort is oorspronkelijk afkomstig uit China; hij wordt gekweekt en is niet meer in het wild bekend. De plant wordt gezien als een levend fossiel omdat het de enig overgebleven soort is ...

Ginkgolide - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/neuroscience/ginkgolide

Ginkgo (maidenhair tree, silver apricot) contains ginkgolides, which inhibit platelet-activating factor, reducing aggregability; this may contribute to bleeding disorders in patients taking Ginkgo. Ginkgo has small beneficial effects in patients with intermittent claudication [ 1 ] and dementias [ 1 , 2 ].

Ginkgolide - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/chemistry/ginkgolide

Ginkgolides are pharmacologically-active diterpenes found in Ginkgo biloba (Ginkgoaceae), which have been widely reported to have several pharmacological properties, including anti-inflammatory effects; for example, Ginkgolides A–C, J and M (Fig. 4).

Biosynthesis pathways of ginkgolides - PMC - National Center for ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731879/

This review focuses on the biosynthetic pathways of ginkgolides, the enzymes related to the biosynthesis of the ginkgolides, the genes encoding the enzymes cloned from the ginkgo, and the factors influencing the production of ginkgolides in cell cultures.

Ginkgolides and Neuroprotective Effects | SpringerLink

https://link.springer.com/referenceworkentry/10.1007/978-3-642-22144-6_146

Ginkgolides were first isolated by Furukawa in 1932 from the root bark of G. biloba [].Maruyama et al. [13–17] and Nakanishi [] isolated and elucidated the structure of ginkgolides G-A, G-B, G-C, and G-M from the root bark.Meanwhile, Okabe and Sakabe independently determined the structures of G-A, G-B and G-C from leaves of G. Biloba by means of X-ray crystallography [19, 20].

Synthetic studies on the ginkgolides: total synthesis of ...

https://pubs.acs.org/doi/10.1021/ja00061a014

Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B. Journal of the American Chemical Society 2022, 144 (39) , 17792-17796. https://doi.org/10.1021/jacs.2c08351

Ginkgo biloba - Orthomoleculair kennisinstituut

https://www.sohf.nl/nutrienten/ginkgo-biloba

Verschillende bestanddelen in ginkgo lijken verschillende effecten te hebben op leverenzymen. De terpenoïde fractie (ginkgolides) lijkt alleen CYP2C9 in vitro te remmen en mogelijk p-glycoproteïne in vivo. 65 De flavonoïde fractie (quercetine, kaempferol, myricetin, enz.) lijkt CYP2C9, CYP1A2, CYP3A4 en CYP2E1 in vitro te remmen. 62,66,68

Frontiers | Role of Ginkgolides in the Inflammatory Immune Response of ...

https://www.frontiersin.org/articles/10.3389/fnsys.2020.00045/full

An excessive IIR is the pathological basis for the generation and development of neurological diseases. Ginkgolides are one of the important medicinal ingredients in Ginkgo biloba. Many studies have verified that ginkgolides have anti-platelet-activating, anti-apoptotic, anti-oxidative, neurotrophic, and neuroimmunomodulatory effects.

A gene cluster in Ginkgo biloba encodes unique multifunctional ...

https://www.nature.com/articles/s41467-022-32879-9

Here, the authors identify five multifunctional cytochrome P450s that catalyze the generation of the tert-butyl group and one of the lactone rings towards the biosynthesis of ginkgolides.

Neuroregulatory role of ginkgolides - Molecular Biology Reports - Springer

https://link.springer.com/article/10.1007/s11033-021-06535-2

Ginkgolides present a wide variety of neuroregulatory properties, commonly used in the therapy process of common diseases, such as Alzheimer’s, Parkinson’s, and many other CNS-related diseases and disorders. The neuroregulative properties of ginkgolides include the conditioning of neurotransmitters action, e.g., glutamate or ...

Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B

https://pubs.acs.org/doi/10.1021/jacs.2c08351

The highly complex molecular architecture of ginkgolides, combined with their remarkable biological profile, provides a unique platform for the development of new strategies and methods. Herein, we reported the first total synthesis of ginkgolide C and the formal syntheses of ginkgolides A and B.

Ginkgolides and bilobalide: Their physical, chromatographic and ...

https://www.sciencedirect.com/science/article/pii/S0968089605004761

Ginkgolides A, B, C, J, K, L and M and bilobalide are rare terpene trilactones that have been isolated from leaves and root bark of the Chinese tree Ginkgo biloba. The structures of the highly oxidized ginkgolides were independently elucidated in the 1960s by the groups of Nakanishi and Sakabe.

Neuroregulatory role of ginkgolides - PMC - National Center for ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338821/

This review focuses on the role of ginkgolides as neurotransmitters or neuromodulators and overviews their impact on the organism at the molecular, cellular, and physiological levels. The clinical application of ginkgolides is discussed as well. Keywords: Ginkgolides, Ginkgo biloba, Neuro-regulation, Neuroprotection.

Ginkgo biloba | Natura Foundation - NF | Home

https://www.naturafoundation.nl/kenniscentrum/monografie/53/ginkgo-biloba

“The ginkgolides: potent platelet-activating factor antagonist isolated from Ginkgo biloba”, Drugs of the future, 1987. Oberplichter H. et al.: “PAF-antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus”, Journal of cerebral blood flow and metabolism, 1990.

Ginkgo biloba, werkingsmechanismen en klinische ... - Stichting OrthoKennis

https://www.orthokennis.nl/artikelen/ginkgo-biloba

Gestandaardiseerde extracten van Ginkgo biloba bladeren bevatten doorgaans 22-27% flavonolglycosiden (vooral mono-, di- en triglycosides en coumarinezuuresters van de flavonolen kaemferol, quercetine en isorhamnetine) en 5-7% unieke terpeenlactonen (ginkgolides, bilobalide).

Ginkgolide

https://www.sciencedirect.com/topics/medicine-and-dentistry/ginkgolide

Ginkgo. Ginkgo (maidenhair tree, silver apricot) contains ginkgolides, which inhibit platelet-activating factor, reducing aggregability; this may contribute to bleeding disorders in patients taking Ginkgo. Ginkgo has small beneficial effects in patients with intermittent claudication [ 1] and dementias [ 1, 2 ].

Role of Ginkgolides in the Inflammatory Immune Response of Neurological ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411855/

Regulating an excessive IIR has become a novel therapeutic target for neurological diseases. Ginkgolides are isolated and purified from the leaves of Ginkgo biloba. The ginkgo leaf extracts commonly contain flavonoids such as quercetin, kaempferol, myricetin, and terpene trilactone (Al-Adwani et al., 2019).