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Ginkgolide - Wikipedia
Ginkgolide B, specifically, is a diterpenoid trilactone with six five-membered rings. It contains a spiro [4,4]-nonane carbocyclic ring, a tetrahydrofuran ring, and a very specific tert-butyl group at one of the rings (Figure 1). The class of ginkgolides was first isolated from the tree Ginkgo biloba in 1932. [2]
Ginkgolide A - an overview | ScienceDirect Topics
Ginkgolides are C20 diterpenes and consist of six five-membered rings; a spiro[4,4]nonane carbocylic ring, three lactones, a tetrahydrofuran, and bilobalide are a sesquinterpene and are the only known natural products with a tert-butyl group (Ude et al., 2013).
Neuroregulatory role of ginkgolides
Ginkgolides belong to the group of terpene trilactones (TTLs) with a unique chemical structure. Ginkgolides are isolated from one of the oldest tree species—Ginkgo biloba tree—the only remaining species of the Ginkoales [1]. Besides ginkgolides, the G. biloba tree is a source of avonoids. The standardized extract from its leaves—EGb
Ginkgolide A: Uses, Interactions, Mechanism of Action - DrugBank
Ginkgolide A. Star 0. Generic Name. Ginkgolide A. DrugBank Accession Number. DB06743. Background. Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders.
Ginkgolides and bilobalide: Their physical, chromatographic and ...
Ginkgolides A, B, C, J, K, L and M and bilobalide are rare terpene trilactones that have been isolated from leaves and root bark of the Chinese tree Ginkgo biloba. The structures of the highly oxidized ginkgolides were independently elucidated in the 1960s by the groups of Nakanishi and Sakabe.
Ginkgolides, diterpene trilactones of Ginkgo biloba, as ... - PubMed
Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. Ginkgolides A, B, and C are diterpene trilactones and active constituents of the 50:1 Ginkgo biloba leaf extract widely used in the symptomatic treatment of mild to moderate dementia. Using the two-electrode voltage ...
The ginkgolides - PubMed
The ginkgolides. The ginkgolides. The ginkgolides Pure Appl Chem. 1967;14(1):89-113. doi: 10.1351/pac196714010089. Author K Nakanishi. PMID: 6036635 DOI: 10.1351/pac196714010089 No abstract available. MeSH terms Alkaloids / analysis* Infrared ...
Ginkgolides and bilobalide: their physical, chromatographic and ...
Ginkgolides A, B, C, J, K, L and M and bilobalide are rare terpene trilactones that have been isolated from leaves and root bark of the Chinese tree Ginkgo biloba. The structures of the highly oxidized ginkgolides were independently elucidated in the 1960s by the groups of Nakanishi and Sakabe.
Biosynthesis pathways of ginkgolides - PubMed
The ginkgolides, acting as anti-platelet-activating factors, have been studied for many years. The biosynthetic pathway of ginkgolides is still far away from unveiling at the level of molecular genetics and biochemistry. There are at least 11 kinds of enzymes having been cloned from Ginkgo biloba L. …
Frontiers | Role of Ginkgolides in the Inflammatory Immune Response of ...
Ginkgolides are one of the important medicinal ingredients in Ginkgo biloba. Many studies have verified that ginkgolides have anti-platelet activating, anti-apoptotic, anti-oxidative, neurotrophic, and neuroimmunomodulatory effects.
Ginkgolide - an overview | ScienceDirect Topics
Ginkgo biloba is an herb whose major constituents include flavonoids and terpene lactones, such as ginkgolides and bilobalide. Ginkgo may have antioxidant, antiplatelet, and hemorrheological actions.230 It is one of the top-selling herbal medicinal products in the United States.
Pharmacokinetics and tissue distribution of ginkgolide A ... - PubMed
These data suggest that ginkgolides have difficulty crossing the blood-brain barrier and that their targets for protecting against cerebral ischaemia are located outside the central system. Keywords: Ginkgo diterpene lactones; Hydrolysates of ginkgolides; LC–MS/MS; Pharmacokinetics; Tissue distribution.
Ginkgo wetenschappelijk bekeken | Mens en Gezondheid: Natuurgeneeswijze
De ginkgolides zijn de meest krachtige en selectieve PAF (Platelet-Activating Factor)-antagonisten die er tot nu toe gevonden zijn. PAF is een sterk werkzame lichaamseigen stof die een rol speelt in veel pathologische situaties.
ginkgolide-B | C20H24O10 - PubChem
ginkgolide-B | C20H24O10 | CID 6324617 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...
ginkgolide-A | C20H24O9 - PubChem
ginkgolide-A | C20H24O9 | CID 9909368 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...
Ginkgolide A - an overview | ScienceDirect Topics
Ginkgolides are terpenoids isolated from Ginkgo biloba. They occur naturally in different forms namely ginkgolides A, B, C, etc. All these forms are in nature bond with the lactone moieties. They act by increasing the cholinergic transmission, which in turn enhances the memory in AD model.
Ginkgolide - an overview | ScienceDirect Topics
The ginkgolides are a unique class of diterpenoids isolated from the ‘fossil’ tree Ginkgo biloba L. This tree is the only remaining species of the Ginkgoales, once a very large order, and its extreme botanical position is matched by the unusual chemistry of its constituents.
Ginkgolides, ginkgolide B | C20H24O10 - PubChem
Ginkgolides, ginkgolide B | C20H24O10 | CID 11973122 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Ginkgolide B | C20H24O10 - PubChem
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Ginkgolides | definition of ginkgolides by Medical dictionary
ginkgolides. A large group of medicinal preparations from a tree in northern China, Ginkgo biloba, which are used by herbalists for cardiovascular and cerebrovascular disease, emotional lability, ocular defects, panic disorder, vertigo and other conditions. Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.