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Ginkgolide - Wikipedia
Ginkgolides are biologically active terpenic lactones present in Ginkgo biloba. They are diterpenoids with 20-carbon skeletons, which are biosynthesized from geranylgeranyl pyrophosphate. [1]
Biosynthesis pathways of ginkgolides - PMC - National Center for ...
This review focuses on the biosynthetic pathways of ginkgolides, the enzymes related to the biosynthesis of the ginkgolides, the genes encoding the enzymes cloned from the ginkgo, and the factors influencing the production of ginkgolides in cell cultures.
Therapeutic promises of ginkgolide A: A literature-based review
Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of sc ….
Role of Ginkgolides in the Inflammatory Immune Response of Neurological ...
Ginkgolides have several different biological effects including inhibiting platelet aggregation, preventing apoptosis and oxidation, providing nutrition to nerves, and regulating neuroimmunity.
Ginkgolide - an overview | ScienceDirect Topics
Ginkgolides are pharmacologically-active diterpenes found in Ginkgo biloba (Ginkgoaceae), which have been widely reported to have several pharmacological properties, including anti-inflammatory effects; for example, Ginkgolides A–C, J and M (Fig. 4).
Ginkgolides and bilobalide: Their physical, chromatographic and ...
Ginkgolides A, B, C, J, K, L and M and bilobalide are rare terpene trilactones that have been isolated from leaves and root bark of the Chinese tree Ginkgo biloba. The structures of the highly oxidized ginkgolides were independently elucidated in the 1960s by the groups of Nakanishi and Sakabe.
Ginkgolide - an overview | ScienceDirect Topics
The ginkgolides are a unique class of diterpenoids isolated from the ‘fossil’ tree Ginkgo biloba L. This tree is the only remaining species of the Ginkgoales, once a very large order, and its extreme botanical position is matched by the unusual chemistry of its constituents.
Ginkgolide - an overview | ScienceDirect Topics
Ginkgolides are diterpenoid trilactone-containing unique C 20 lactone cage molecules that are the main principles from the slow-growing Ginkgo biloba L. (especially from leaf part), which are from gymnospermous tree, species in the division ginkgophyta, and a single surviving species belonging to the family of ginkgoaceae in a class of ...
Ginkgo wetenschappelijk bekeken - Mens en Gezondheid
De ginkgolides zijn de meest krachtige en selectieve PAF (Platelet-Activating Factor)-antagonisten die er tot nu toe gevonden zijn. PAF is een sterk werkzame lichaamseigen stof die een rol speelt in veel pathologische situaties.
Neuroregulatory role of ginkgolides - PubMed
The neuroregulative properties of ginkgolides include the conditioning of neurotransmitters action, e.g., glutamate or dopamine. Besides, natural compounds induce the inhibition of platelet-activating factors (PAF). Furthermore, ginkgolides influence the inflammatory process.
Biotechnological approaches to enhance the biosynthesis of ginkgolides ...
Different biotechnological strategies to improve ginkgolides and bilobalide production will be discussed, including screening and selection of in vitro ginkgo cultures, cell differentiation levels of these cultures, optimization of culture conditions, feeding and elicitation strategies.
Synthetic studies on the ginkgolides: total synthesis of ...
Ginkgolides and bilobalide: Their physical, chromatographic and spectroscopic properties. Bioorganic & Medicinal Chemistry 2005 , 13 (17) , 5001-5012. https://doi.org/10.1016/j.bmc.2005.05.056
Ginkgolide - an overview | ScienceDirect Topics
Ginkgolides are diterpenoid trilactone-containing unique C20 lactone cage molecules that are the main principles from the slow-growing Ginkgo biloba L. (especially from leaf part), which are from gymnospermous tree, species in the division ginkgophyta, and a single surviving species belonging to the family of ginkgoaceae in a class of ...
Neuroregulatory role of ginkgolides - Springer
role of ginkgolides as neurotransmitters or neuromodulators and overviews their impact on the organism at the molecular, cellular, and physiological levels. The clinical application of ginkgolides is discussed as well.
Frontiers | Role of Ginkgolides in the Inflammatory Immune Response of ...
Ginkgolides are one of the important medicinal ingredients in Ginkgo biloba. Many studies have verified that ginkgolides have anti-platelet-activating, anti-apoptotic, anti-oxidative, neurotrophic, and neuroimmunomodulatory effects.
Neuroregulatory role of ginkgolides - PMC - National Center for ...
This review focuses on the role of ginkgolides as neurotransmitters or neuromodulators and overviews their impact on the organism at the molecular, cellular, and physiological levels. The clinical application of ginkgolides is discussed as well. Keywords: Ginkgolides, Ginkgo biloba, Neuro-regulation, Neuroprotection.
Neuroregulatory role of ginkgolides | Molecular Biology Reports - Springer
The neuroregulative properties of ginkgolides include the conditioning of neurotransmitters action, e.g., glutamate or dopamine. Besides, natural compounds induce the inhibition of platelet-activating factors (PAF). Furthermore, ginkgolides influence the inflammatory process.
Ginkgolide - an overview | ScienceDirect Topics
The ginkgolides are a unique class of diterpenoids isolated from the ‘fossil’ tree Ginkgo biloba L. This tree is the only remaining species of the Ginkgoales, once a very large order, and its extreme botanical position is matched by the unusual chemistry of its constituents.
Therapeutic promises of ginkgolide A: A literature-based review
Abstract. Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of scientific reports in the ...
Exploring the multifaceted role of ginkgolides and bilobalide from
Ginkgolides A, B, and C, and bilobalide have unique pharmacological properties, including anti-inflammatory, antioxidant, antitumor, and neuroprotective effects. Importantly, they exhibit promise in tackling metabolic diseases, such as dyslipidemia and obesity-related complications.
A gene cluster in Ginkgo biloba encodes unique multifunctional ...
Here, the authors identify five multifunctional cytochrome P450s that catalyze the generation of the tert-butyl group and one of the lactone rings towards the biosynthesis of ginkgolides.
Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A ...
The highly complex molecular architecture of ginkgolides, combined with their remarkable biological profile, provides a unique platform for the development of new strategies and methods. Herein, we reported the first total synthesis of ginkgolide C and the formal syntheses of ginkgolides A and B.
The neuroprotective mechanisms of ginkgolides and bilobalide in ...
This review seeks to elucidate the neuroprotective effects and mechanisms of ginkgolides, especially GA and GB, and bilobalide in cerebral injury following ischemic strokes. The incidence and mortality of strokes have increased over the past three decades in China.