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Ginkgolide - Wikipedia

https://en.wikipedia.org/wiki/Ginkgolide

Ginkgolide B, specifically, is a diterpenoid trilactone with six five-membered rings. It contains a spiro[4,4]-nonane carbocyclic ring, a tetrahydrofuran ring, and a very specific tert-butyl group at one of the rings (Figure 1). The class of ginkgolides was first isolated from the tree Ginkgo biloba in 1932.

Ginkgolides, diterpene trilactones of Ginkgo biloba, as ... - PubMed

https://pubmed.ncbi.nlm.nih.gov/15212966/

Ginkgolides A, B, and C are diterpene trilactones and active constituents of the 50:1 Ginkgo biloba leaf extract widely used in the symptomatic treatment of mild to moderate dementia. Using the two-electrode voltage clamp methodology, these ginkgolides were found to be moderately potent antagonists at recombinant human alpha(1)beta(2)gamma(2L) GABA(A) receptors expressed in Xenopus oocytes.

Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A ...

https://pubs.acs.org/doi/10.1021/jacs.2c08351

Ginkgolides are diterpenes isolated from Ginkgo biloba that exhibit strong anti-inflammatory and neuroprotective properties. The highly complex molecular architecture of ginkgolides, combined with their remarkable biological profile, provides a unique platform for the development of new strategies and methods. Herein, we reported the first total synthesis of ginkgolide C and the formal ...

Ginkgolide A ameliorates non-alcoholic fatty liver diseases on ... - PubMed

https://pubmed.ncbi.nlm.nih.gov/28142119/

The effects of Ginkgolide A (GA), derived from the ginkgo biloba leaf, are still unknown in NAFLD. To determine the protective effects of GA in NAFLD, we examined the fatty liver disease condition in the non-esterified fatty acid (NEFA)-induced HepG2 cell line and in a high fat diet mouse model.

The neuroprotective mechanisms of ginkgolides and bilobalide in ...

https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0125-y

Ginkgolides include Ginkgolide A (GA), Ginkgolide B (GB), Ginkgolide C (GC), Ginkgolide J (GJ), Ginkgolide K (GK), Ginkgolide L (GL), and Ginkgolide M (GM). Extensive evidences have shown that Ginkgo biloba extracts have neuroprotective properties under conditions such as hypoxia/ischemia, seizure activity and peripheral nerve damage.

Ginkgolides | definition of ginkgolides by Medical dictionary

https://medical-dictionary.thefreedictionary.com/ginkgolides

ginkgolides. A large group of medicinal preparations from a tree in northern China, Ginkgo biloba, which are used by herbalists for cardiovascular and cerebrovascular disease, emotional lability, ocular defects, panic disorder, vertigo and other conditions. Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Ginkgolide | definition of Ginkgolide by Medical dictionary

https://medical-dictionary.thefreedictionary.com/Ginkgolide

ginkgolides. Alternative pharmacology. A large group of medicinal preparations from a tree in northern China, Ginkgo biloba, which are used by herbalists for cardiovascular and cerebrovascular disease, emotional lability, ocular defects, panic disorder, vertigo and other conditions. Segen's Medical Dictionary. © 2012 Farlex, Inc.

The therapeutic effects of ginkgolides in Guillain-Barré syndrome and ...

https://pubmed.ncbi.nlm.nih.gov/33863532/

Background: Guillain-Barré syndrome (GBS) is an acquired immune-mediated inflammatory peripheral neuropathy. The immune regulation of ginkgolides have been revealed in recent years. We herein investigate the potential therapeutic effects of ginkgolides both on GBS and its animal model, experimental autoimmune neuritis (EAN).

Frontiers | Role of Ginkgolides in the Inflammatory Immune Response of ...

https://www.frontiersin.org/articles/10.3389/fnsys.2020.00045/full

Ginkgolides are one of the important medicinal ingredients in Ginkgo biloba. Many studies have verified that ginkgolides have anti-platelet activating, anti-apoptotic, anti-oxidative, neurotrophic, and neuroimmunomodulatory effects.

The protective mechanism of Ginkgolides and Ginkgo flavonoids on the ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939806/

So, Ginkgolides and Ginkgo flavonoids might exert its anti-apoptotic role through synergistically regulating TNF-a receptor and apoptosis genes. Therefore, we examined whether TNF-α could induce apoptosis of hippocampal neurons and whether the neuroprotective role of Ginkgolides and Ginkgo flavonoids were through death receptor-mediated pathway and mitochondrial pathway.

Ginkgolide A - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/medicine-and-dentistry/ginkgolide-a

The ginkgolides are diterpenes and are known to be platelet-activating factor (PAF) antagonists. Numerous studies have shown that the ginkgolides antagonize many of the effects of PAF, including inflammation, bronchoconstriction, bronchial hyperresponsiveness, platelet aggregation and allergic responses.

Ginkgolide - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/neuroscience/ginkgolide

Ginkgo biloba is an herb whose major constituents include flavonoids and terpene lactones, such as ginkgolides and bilobalide. Ginkgo may have antioxidant, antiplatelet, and hemorrheological actions.230 It is one of the top-selling herbal medicinal products in the United States.

ginkgolide-C | C20H24O11 - PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/9867869

ginkgolide-C | C20H24O11 | CID 9867869 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...

Ginkgo wetenschappelijk bekeken | Mens en Gezondheid: Natuurgeneeswijze

https://mens-en-gezondheid.infonu.nl/natuurgeneeswijze/83239-ginkgo-wetenschappelijk-bekeken.html

De ginkgolides zijn de meest krachtige en selectieve PAF (Platelet-Activating Factor)-antagonisten die er tot nu toe gevonden zijn. PAF is een sterk werkzame lichaamseigen stof die een rol speelt in veel pathologische situaties.

Ginkgolides - Journal of the Chemical Society C: Organic (RSC Publishing)

https://pubs.rsc.org/en/content/articlelanding/1967/j3/j39670002201

Since the structure of ginkgolide A was established by X -ray analysis of its p -bromobenzoate, structures of the other two were deduced by comparison of the n.m.r. spectra of the three compounds. The structures of ginkgolides A and B were correlated by chemical methods. Owing to its complex structure, ginkgolide A gave an unusual oxidation ...

Ginkgolide A - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/neuroscience/ginkgolide-a

Currently Ginkgo is used clinically to treat a range of circulatory disorders and dementia. Chemical screening of this plant revealed that it contains a range of valuable compounds, such as ginkgolides (A, B, C, J and M), bilobalide,3,3'-dimethoxy-4,4'-dihydroxy-stilbene, aglycones, quercetin, kaempferol, isorhamnetin, bilobol and cardanol. 101,102

Ginkgolide - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/medicine-and-dentistry/ginkgolide

The ginkgolides are diterpenes and are known to be platelet-activating factor (PAF) antagonists. Numerous studies have shown that the ginkgolides antagonize many of the effects of PAF, including inflammation, bronchoconstriction, bronchial hyperresponsiveness, platelet aggregation and allergic responses.

Ginkgolide - an overview | ScienceDirect Topics

https://www.sciencedirect.com/topics/chemistry/ginkgolide

Ginkgolides are pharmacologically-active diterpenes found in Ginkgo biloba (Ginkgoaceae), which have been widely reported to have several pharmacological properties, including anti-inflammatory effects; for example, Ginkgolides A–C, J and M (Fig. 4).

Ginkgolide B | C20H24O10 - PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/Ginkgolide-B

Ginkgolide B | C20H24O10 | CID 65243 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ...

Ginkgolides, ginkgolide B | C20H24O10 - PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/Ginkgolides_-ginkgolide-B

Ginkgolides, ginkgolide B | C20H24O10 | CID 11973122 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

JACS:二萜Ginkgolides A-C的统一式合成_CBG资讯

https://www.chembeango.com/zixun/57362

Ginkgolides是从“活化石”银杏树的树叶和根皮中分离出的一类复杂的高氧化态二萜天然产物。加拿大渥太华大学(University of Ottawa)的Louis Barriault课题组报道了二萜类天然产物ginkgolides A-B的形式合成和ginkgolide C的首次全合成。该研究工作通过一系列非对映选择性C-C键构建反应和细致的氧化反应来实现 ...